HGH and IGF-1: What You Absolutely Must Know!

HGH and IGF-1 work hand in glove with one another. You must track your IGF-1 levels to confirm your dose of HGH is properly prescribed.

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The Role of HGH and IGF-1 in Growth Hormone Therapy

Insulin-like growth factor 1 (IGF-1) plays a crucial role in growth hormone therapy for both children and adults. Growth hormone (GH) is produced by the pituitary gland and stimulates the liver to produce IGF-1, which in turn promotes the growth and development of bones, muscles, and other tissues.

In children with a growth hormone deficiency, HGH therapy is used to stimulate the production of IGF-1 and promote growth. HGH therapy is usually given as a daily injection, and the dosage is adjusted based on the child’s weight and response to treatment. Over time, the therapy can help children with growth hormone deficiency achieve normal height and weight.

In adults, HGH therapy is used to treat a variety of conditions, including growth hormone deficiency, muscle wasting due to HIV/AIDS, and short bowel syndrome. In these cases, HGH therapy can help increase muscle mass, reduce body fat, and improve the overall quality of life of the individual. Again, the therapy works by stimulating the liver to produce IGF-1, which in turn promotes the growth and regeneration of muscle and other tissues.

Optimal Levels of IGF-1 for Growth Hormone Therapy

A little-known but controversial subject is using the indirect assay of IGF-1 levels to measure growth hormone production. Measuring IGF-1 and using it to benchmark optimal HGH production is the smart way to measure the quality of your body’s HGH production. It is also a relatively inexpensive blood test to have done. 

If you would like to order your own blood test for IGF-1 to check your levels, you can usually find an online lab that will perform the test for under $100 dollars. If you are an adult concerned about the production of your HGH levels, we encourage you to do a self-check. Most family doctors in the United States will rarely prescribe this test for their patients unless they suspect a tumor. 

DirectLabs IGF-1 Testing: Search for the IGF-1 Test. Be sure to use the code R-ALUVA. 

Interpreting IGF-1 Results

As we age, our pituitary begins to produce less and less HGH. This in turn lowers our insulin-like growth factor 1 (IGF-1). This is good for the most part. Otherwise, we would continue to grow like giants. In fact, some people with tumors on their pituitary suffer from these problems. 

Some have reported that Tony Robbins, the famous self-help guru, has a pituitary tumor that makes him grow, but this information is not confirmed or supported by any official medical records or statements from Tony Robbins himself.

It is true that some pituitary tumors can cause excessive production of growth hormone, leading to a condition called acromegaly. However, without a medical diagnosis from a qualified healthcare provider, it is impossible to say whether or not Tony Robbins has a pituitary tumor or any other medical condition that could be affecting his growth.

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The photo to the right (below on mobile phones) represents an individual with acromegaly who is standing next to an average-sized male. He suffered from excess production of HGH from his pituitary during adolescence and beyond. So when taking HGH, it is always best to periodically review your IGF-1 levels a couple of times per year to confirm your levels are within the normal physiological range. 

Popular Method for Indirect Assay of HGH and IGF-1

We use the chart levels below to determine the optimal range of IGF-1 for our patients on human growth hormone replacement. The level of IGF-1 for a healthy adult is between 290-315 ng/ml. We generally try to get our patients in a range near the upper side of this range. This is where most people receive the benefits of HGH without risking negative side effects. 

Pituitary Description of Blood Test IGF-1 Range ng/mL
IGF-1 IGF-1 levels are directly related to growth hormone secretion and/or HGH therapy. Best levels for healthy adults is in the upper physiological range (290-315ng/ml). Some patients will require HGH dosage adjustments to achieve optimal levels of IGF-1. 200-320 ng/ml

The HGH / IGF-1 table above was reconstructed from the book Dr. Jeffry S. Life, M.D. Ph.D., The Life Plan: How Any Man Can Achieve Lasting Health, Great Sex, and a Stronger, Leaner Body, Edition May 2011, page 323.

Avoiding Excessively High Levels of Growth Hormone in Older Adults

It is important to receive treatment for growth hormone replacement from a qualified medical team to reduce the risk of side effects. Inexperienced users not seeking appropriate medical advice often take excessive amounts of HGH injections. This can lead to dangerous side effects. 

It’s important to monitor and not exceed the upper physiological range of IGF-1. High levels of IGF-1 may put you at an increased risk of certain types of cancer, such as breast, prostate, or colon cancer, as well as other health conditions. While low levels of IGF-1 may indicate a deficiency or imbalance in the body’s growth and development processes or may be a sign of poor diet or other health problems. 

The optimal dose of HGH was shown to reduce the negative effects of PD1 biomarker level, reducing the risk of cancer by boosting immune system function. See more on the TRIIM Protocol.

IGF-1 Decline by Decade on Average from Age 20 to 80

The decline of IGF-1 levels from age 20 through age 80 varies from person to person and is affected by various factors, including genetics, lifestyle, and health status. However, studies have shown that there is a general decline in IGF-1 levels with age. Here is a rough estimate of the decline in IGF-1 levels from age 20 through age 80 in ten-year increments, based on data from multiple studies:

  • Between the ages of 20 and 30, IGF-1 levels decline by about 14% on average.
  • Between the ages of 30 and 40, IGF-1 levels decline by about 12% on average.
  • Between the ages of 40 and 50, IGF-1 levels decline by about 11% on average.
  • Between the ages of 50 and 60, IGF-1 levels decline by about 10% on average.
  • Between the ages of 60 and 70, IGF-1 levels decline by about 12% on average.
  • Between the ages of 70 and 80, IGF-1 levels decline by about 15% on average.

Again, it’s important to note that these numbers are rough estimates and may not apply to every individual. Additionally, while IGF-1 levels tend to decline with age, this decline can be slowed or reversed through various interventions, such as exercise, diet, and HGH therapy.

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The Anti-Aging & Weight Loss Center by Age Metrics Medical is part of the original Anti-Aging and Wellness Medical Clinic (Est. 2013). The clinic is one of the longest-running most successful anti-aging centers in all of Latin America for Weight Loss and Anti-Aging and Wellness therapies. Our doctors are US board-certified in Anti-Aging and Regenerative Medicine by the A4M.

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Providing evidence-based Anti-Aging, Weight Loss, and Regenerative therapies. All of our treatment programs are supervised medically by Dr. Jeff Ugalde, MD. He has been part of the Anti-Aging and Wellness team since 2014 serving as its Medical Director. He is the most experienced doctor in Anti-Aging Medicine in Costa Rica. He has over 20 years of experience as a physician and is US board certified by the American Academy of Anti-Aging and Regenerative Medicine. 

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