Metabolic Syndrome HGH | Alternative Treatments | Diet, and BHRT

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How Intermittent Fasting, Intermittent Ketosis, HGH, Testosterone, Metformin, NMN (NAD+) and more can influence healthy aging...

Metabolic syndrome HGH, metformin and hormone replacement

New forms of blood tests help measure and track biological age. These tests are helping researchers develop and refine new dietary and supplementation protocols, including hormone therapy, that show promise for reversing the clock of biological age. With these tests, scientists are narrowing in on protocols and interventions we can do today that have promise for extending health-span and perhaps reverse biological age.

Biological age is a much more precise measure of aging than chronological age. 

Research widely published over the past 2-5 years shows how intermittent fasting, ketogenic dieting, hormone therapy, insulin resistance therapy, and other molecules may have the power to reverse our biological clocks and extend health-span.

In this blog, we discuss the problem and interventions we can undertake today that can benefit the majority of those who may be suffering from some form of age-related chronic disease. The topics we discuss are:

  1. Fasting, Intermittent Fasting, Fasting Mimicking Diets, Ketogenic Dieting.
  2. Hormone Replacement (HGH, Testosterone and others).
  3. Metformin, a widely used anti-diabetic drug now being studied for its anti-aging properties.
  4.  NAD+ – NMN – The fuel for our cellular power cells, the mitochondria.

Chronological age is a major risk factor for chronic diseases, musculoskeletal injury, and mortality. Yet, still, some fall into a subset of the population that remains youthful and healthy well in their 70s, 80s and beyond. However, in recent years we’ve seen a turn for the worse in the health of the population. Heart disease, cancers, and diabetes are creating a healthcare crisis. Nearly 70% of the population is either overweight or obese. No children more than ever are developing type II diabetes.

For years healthcare has approached most age-related chronic diseases as isolated and independent problems. That is, if you have heart trouble, you get assigned a specialist called a cardiologist. If you have cancer, diabetes or kidney failure, you again get assigned to another medical specialist trained for treating those diseases. Each one of these specialists treats your disease independently, at least to varying degrees, without much consideration of the complete physiology of the body.

For decades, scientific evidence has been telling us something different, but many in the medical profession haven’t been listening. Research provides clues that most diseases are likely in large part caused by lifestyle. What we eat along with smoking, drugs, and alcohol.  As our population continues to gain weight, our leading chronic diseases are coming much sooner in life.

Heart Disease kills over 600,000 annually in the USA. Cancer kills over 590,000 people each year and with billions spent on researching its causes since the 1970s, we haven’t reduced annual mortality rates. Some argue that if we cured cancer, total life expectancy wouldn’t increase all that much, because one of the other leading killers would get us anyway. 

Metabolic syndrome - leading causes of death USA - Anti-Aging and Wellness
Leading Causes of Death USA

The chart above reflects the typical leading causes of death in the United States. These numbers are generally published by the CDC. This chart was adapted from data published in 2016 by Johns Hopkins and the National Center for Health Statistics.  Johns Hopkins’ researchers discovered that the third leading cause of death was actually due to medical error.  

  1. Heart Disease kills over 600,000 people each year in the United States.
  2. Cancer kills over 590,000 each year in the United States.
  3. Medical Error kills approximately 250,000 each year because so many people are chronically ill and in and out of hospitals. They increase their odds of dying from medical error. 

Most of the remaining diseases listed, with the exception of accidents and suicide, have a close relationship to all age-related chronic diseases higher on the list.

Many of these deaths can be avoided with proper information and lifestyle. One big paradigm shift to fighting chronic disease is the study and practice of anti-aging medicine. Now that new and advanced testing capabilities exist, a scientist can study reducing the one big common denominator with all chronic disease, age. If we can slow and reverse the biological age of people, the hope is we can increase and improve the lives of millions. 

Two things we know for sure:

  1. Epigenetic aging can be slowed. In fact, it may be proven soon that epigenetic aging can even be reversed much faster than once believed. 
  2. Your age is inversely related to chronic diseases for most people. Few youths die of heart attacks or Alzheimer’s, so if we can slow the aging process, we can potentially delay early deaths due to many of the leading chronic diseases killing Americans each year and costing the healthcare industry billions. 

If we can slow or reverse aging, we can begin to improve life expectancy since many of our major diseases killing most Americans today are related to age-related chronic diseases like heart disease, cancer, diabetes, Alzheimer’s, stroke, and others. 

Fasting, Intermittent Fasting, Fasting Mimicking, and Ketogenic Dieting

Fasting comes in many forms. It has been used in medicine for thousands of years. Recently it is making a comeback among health researchers.

Fasting is a physiological process that when done therapeutically can provide many health benefits. Various fasting protocols may be used. There is water fasting, fasting-mimicking, intermittent fasting, and ketogenic diets which simulate a fasted state. When done properly, most forms of fasting offer similar metabolic benefits.

In order to receive the maximum benefit from a fast, one needs to get into a state of nutritional ketosis. This is when your metabolism switches from using mostly glucose for energy to using ketone bodies. In this state, the body begins to oxidize fat stores to make ketone bodies in the liver for energy. 

This has been studied extensively by many researchers. Two famous researchers who have been some of the longest proponents of healthy nutritional ketosis are Stephen Phinny, MD and Jeff Volek, Ph.D. See their PubMed research paper on the keto-adaptation state for endurance athletes here: <Click here>.

One of the key elements of fasting is getting the body in a state of nutritional ketosis. When the body senses that it is without food for a short period of time (usually between 24-36 hours), it sets into place a cascade of events that are now recognized as beneficial with anti-aging properties. This does not suggest one should fast indefinitely.

Short-term periods of fasting, fasting-mimicking, or ketogenic dieting can be extremely beneficial for those with Metabolic Syndrom. 

Ideally, we recommend patients review some of Dr. Phynney’s and Volek’s work. 

HGH Metabolic Syndrome - Nutritional Ketosis

The chart is taken from Dr. Volek’s research. It appears that short periods of ketosis in the 2.6 mmol/L one or two times per week can be extremely beneficial for those individuals with metabolic syndrome.

This is a 1-hour presentation by Jeff Volek, Ph.D. for those interested in understanding nutritional ketosis and keto-adaptation for health, wellness and endurance. 

Jason Fung, MD - Reversing Diabetes (Type 2)

Hormone Replacement

Hormone replacement has been demonized for decades. Media sensationalized athletes doping on synthetic hormones for performance enhancement. Yet, research continues to point to benefits. Primarily at improving body composition, age-related disease markers, and epigenetic age markers (anti-aging). 

See the latest Anti-Aging Research Study using HGH, Metformin, and DHEA. Epigenetic aging markers should a reversal in biological age by approximately 2.5 years on average.  The study was small, only 9 people. But it is more positive news related to human growth hormone, glycemic control, and supplementation role with anti-aging and age management in aging adults.

Reversal of epigenetic aging and immunosenescent trends in
humans using HGH, Metformin, and DHEA Supplementation: <Download pdf>.

Hormones are communication messenger signals and important regulatory pathways for optimal health. Hormone decline used to be considered a normal part of aging. New research may indicate that hormone decline is accelerating faster in younger adults in past generations. This is most likely related to our lifestyle and overweight/obesity epidemic. Approximately 70% of our population is overweight and/or obese? Body mass index is associated with age-related chronic disease.

Optimizing hormone levels properly helps improve energy levels, body composition, and exercise capacity. 

Additional Research used:

  • Morgentaler article <Click here>.
  • Morgentaler article 2016 Mayo <Click here>.
  • Type II diabetes improvement with testosterone replacement in men <Click here>.

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Metabolic syndrome, HGH and Anti-Aging
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Does HGH help Metabolic Syndrome?

On PubMed you can find the study:

Growth hormone and the metabolic syndrome.

Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Göteborg, Sweden.

  1. Point 1:  The association of several risk factors including, obesity, dyslipoproteinemia, hepatic steatosis, insulin resistance and hypertension with Type 2 (non-insulin-dependent) diabetes mellitus and myocardial infarction has long been known and has been termed the “metabolic syndrome”.
  2. Point 2:  Type 2 diabetes and cardiovascular morbidity is the mass of intraabdominal fat. Striking similarities exist between the metabolic syndrome and untreated growth hormone (GH) deficiency in adults.
  3. Point 3: The main association is abdominal/visceral obesity and insulin resistance. Other features common to both conditions are premature atherosclerosis and increased mortality from cardiovascular diseases. These similarities indicate that undetectable and low levels of GH may be of importance in the metabolic aberrations observed in both these conditions. 
  4. Point 4: Nine months of GH treatment reduced their total body fat and resulted in a specific and a marked decrease in both abdominal subcutaneous and visceral adipose tissue. Moreover, insulin sensitivity improved and serum concentrations of total cholesterol and triglyceride decreased. Diastolic blood pressure also decreased. The finding that GH replacement in men with abdominal obesity can diminish the negative metabolic consequences of visceral obesity suggests that low levels of this hormone are of importance for the metabolic aberrations associated with visceral/abdominal obesity.


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NAD+ (NMN) and its Role in Anti-Aging

Dr. Sinclair of Harvard discusses his work and views on anti-aging. Much of his recent research is how NAD+ supplementation supports energy metabolism via the electron transport chain. As we age, this molecule declines. By replenishing this simple supplement, we improve the efficiency and health of our mitochondria. He is extending the health and lifespan already in the lab using NAD+ and its support for longevity.

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