Metformin Anti-Aging

The Metformin anti aging drug for Longevity: 2019 Study shows Epigenetic Biomarker Improvements with Metformin, Diet and HGH.

Norditropin Pen Metformin for Anti-Aging

Metformin, Growth hormone, DHEA and other supplements now in clinical studies for reversal of epigenetic age markers. The markers are evidence for considering metformin for longevity purposes.

Same Medication – Same Manufacturer
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Metformin Anti Aging: New Research on Metformin and Longevity Epigenetics

Metformin is a common first-line drug for type-2 diabetes that is now being studied for anti-aging. Metformin is a medication that has been used by millions of people for decades and is considered extremely safe when taken according to instructions. 

More recently, it’s been approved for trials on its potential for extending human healthspan and longevity. Its anti-aging effects appear to influence metabolic pathways that aid in turning off bad genes and flipping on longevity genes. This, of course, positively influencing the aging process. In fact, it can help switch on key longevity genes that may improve healthspan and longevity in humans for decades or more. 

Metformin is currently being studied throughout the world in major research institutions for this very reason. This combined with a healthier lifestyle can add years or decades to your life. 

Metformin key component of 2019 FAHY Anti-Aging Study

Overview of Metformin and its Role in Anti-Aging in Humans

Aging in humans is a well-established primary risk factor for many disabling diseases and conditions, among them diabetes, cardiovascular disease, Alzheimer’s disease, and cancer.

For example, the risk of death from these diseases accelerates up to one-thousand times between the ages of thirty-five and eighty-five years in humans.

For this reason, the U. S. medical community is finally considering anti-aging medicine as a real science. They are investigating the development of new interventions to improve and maintain health in old age.

Ideally, to improve human health span and quality of life. This is Anti-Aging Medicine.

Anti-Aging and Wellness have been around for many years. Those who practiced anti-aging medicine used to be demonized and ridiculed, but now the tides are turning.

We believe the new Anti-Aging community is on the march, and the out-dated consensus-based medical establishment is on the run. It’s processes no longer fit the modern information model and doctors and practitioners are unlikely to get the information they need as fast as patients willing to research on their own.

Metformin is one important of many medicines with anti-aging potential.

Metformin is an FDA-approved first-line drug for the treatment of type 2 diabetes, and has known beneficial effects on glucose metabolism. It has been used for decades by millions of type 2 diabetics and is considered safe.

What’s more, evidence from animal models and human tissue studies suggest that in addition to its effects on glucose metabolism, metformin may influence metabolic and cellular processes associated with the development of age-related conditions, such as inflammation, oxidative damage, diminished autophagy, cell senescence, and cell apoptosis.

Because of this, metformin has been used by the anti-aging community for years to help control glucose metabolism. It is now being studied in the United States for aging since it may influence fundamental aging factors that underlie multiple age-related conditions.

Soon when the FDA-approved anti-aging studies are completed on metformin, we believe we will see that metformin will restore the gene expression profile of older adults with impaired glucose tolerance to that of a younger age person.

One small study in California showed this with nine adults. After taking metformin, human growth hormone, and D H E A for one year, the group showed an average of two and one-half years of age reversal at the cellular level.

At the anti-aging and wellness treatment centers, we’ve been prescribing metformin since we opened our doors in 2013, along with human growth hormone, and D H E A, in Mexico, Costa Rica, and Panama.

The three primary reasons patients look to us:

  1. Experience. We have experience in metformin, growth hormone, and energy metabolism.
  2. Commitment to Patient Success: We have a sincere desire to work closely with patients. We understand and have observed for years the beneficial improvement in patients by altering the growth hormone-IGF-1 pathways in combination with blood glucose regulation and its benefits to energy metabolism.
  3. The best part of all of this is that our treatment costs are one-third the price at our treatment centers in Mexico, Costa Rica, and Panama.

Go to to sign up. That’s,

Metformin as Anti-Aging Therapy: Is It for Everyone?

No. Metformin is only beneficial for type-2 diabetics. Lactic acidosis can occur in patients who overdose on metformin. This is why a doctor must work closely with patients. 

The possibility of lactic acidosis is the riskiest among type 1 diabetics who do not produce insulin. 

Always work closely with a knowledgeable healthcare professional knowledgeable in optimal metformin protocols for blood glucose regulation. 

TAME Trial (Targeting Anti Aging with Metformin)

The goal of the TAME trial is to look at metformin’s potential role in extending health, decreasing incidents of chronic disease, and helping increase our health span. That is, increases our ability to live independently and free from debilitating disease states. 

For more than 100 years, modern allopathic medicine has been targeting specific diseases independent of one another. Each disease was often treated by a specialist in that disease (e.g., a cardiologist). Since our leading diseases are strongly associated with aging, scientists are now looking at using medications like metformin to influence aging pathways. 

Age-related chronic diseases metformin may improve:

  • Heart disease
  • Diabetes
  • Cancer
  • Dementia
  • Alzheimer’s

The TAME trial is the first step which will lead to the following future actions as described in the TAME executive summary:

  1. Establish proof of concept with metformin trials.
  2. Obtain an indication status from the FDA for treating aging.
  3. Slow down major age-related chronic diseases by targeting aging pathways.
  4. Develop next-generation drugs that improve upon some of the existing benefits observed from metformin.

If metformin studies succeed, hundreds of thousands of lives may be saved each year from age-related chronic diseases. Metformin should not be the only intervention, we also promote lifestyle coaching on diet and nutrition.  

Each year the CDC reports over 600,000 deaths annually due to heart disease, and 590,000 deaths annually due to cancers, For a detailed breakdown see the infographic below. 

Anti Aging Metformin
Source: National Ceter for Health Statistics

The Role of Metformin for Anti Aging & Longevity

For years the anti-aging movement has targeted certain effects of aging through hormone replacement and dietary manipulation.  We now are exploring a deeper role of energy metabolism with metformin for aging, especially in a world with such an abundance of processed foods.

Metformin has demonstrated protective effects against several age-related diseases in humans [Metformin as a Tool to Target Aging, Nir Barzilai,].

Metformin for Anti Aging: Human Metabolic Pathways that Influence Disease and Longevity

In recent years a better understanding of the metabolic pathways responsible for aging has been identified and evaluated in animals and humans. According to some, the aging process is characterized metabolically by insulin resistance, changes in body composition (being overweight), and physiological declines in growth hormone.

The main factor contributing to insulin resistance and growth hormone decline is being overweight or obese. Most of which is likely due to poor lifestyle choices. Essentially, eating too many processed foods and eating too frequently. 

Growth Hormone Decline

With the passing of each year, growth hormone decline accelerates. The human growth hormone is an important hormone for cellular regeneration, building strong muscles, healthy bones, and higher immunity. 

In our modern population, most of us are overweight, obese and experience chronic stress more so than prior generations. These elements combined can trigger a cascade of events that negatively impact energy metabolism and optimal hormone regulation.  

Our goal for a number of years has been to measure hormone decline more closely and replace these declines with bioidentical hormone replacement therapy.

When low levels of hormones negatively impact your health, wellness, and quality of life, we work to improve them through diet, hormone replacement, and supplements. 

By incorporating cutting-edge dietary protocols that are simple for patients to understand and comply with, along with hormone therapy, metformin, DHEA and other vitamins and micronutrients, quality of life and age-related biomarkers can improve significantly. 

No one can make time go backward, but we now have insight into how to target key human pathways that have shown positive results in the form of increasing longevity biomarkers. 

HGH Average Decline by Age

Peter Thiel - Longevity to 120 Yrs.

History of Metformin

Metformin originates from traditional herbal medicine in Europe. It was discovered in 1918 to lower blood glucose levels [Metformin: Historical Overview, Bailey, CJ].

It was first used to treat diabetes in 1957 by a French physician named Jean Sterne. However, there were other medications that lowered blood glucose levels better than Metformin at the time. Those medications were known as phenformin and buformin. Both medications were discontinued in the 1970s because of side effects due to the risk of lactic acidosis.

Eventually, Metformin was re-evaluated and approved for use in the USA in 1995.

Anti-Aging - Is it for real? Can Metformin Influence Longevity in Humans?

In animal studies, researchers have extended the lifespan and improved age markers through calorie restriction. The only problem is it creates angry animals and is considered impractical for humans. Metformin seems to mimic some or all of the benefits of calorie restriction without the restriction of calories. It does this by influencing the same metabolic pathways as what occurs under a caloric-restricted diet. This process may lead to using metformin as a true anti-aging medication sometime in the future. 

For years opponents of the anti-aging movement have criticized its practice. But more recently, it is being taken more seriously. Not only for slowing the aging process but also for disease prevention and perhaps cellular age reversal.

Many large age management groups ridiculed the anti-aging movement for years. They claimed cellular anti-aging is an impossibility and treated its practice as quackery. They drafted, published, and released public documents attacking anti-aging groups such as the American Academy of Anti-Aging and disparaged many of their doctors. Repeatedly they lumped them together with doctors and pharmacies that broke the law, akin to guilt by association when the vast majority of the doctors associated with the American Academy of Anti-Aging were doing good work.

For approximately half a decade countless patients who may have benefited from the progress being made by following a solid anti-aging lifestyle program were scared away, due to sensational attacks on the industry. 

Now we have a new generation of scientists who are open to questioning the status quo and consensus-based dogma. Longevity and anti-aging are being done in the lab, the chemical pathways are well understood, and even though there is much more to learn, we know eating a whole food diet, managing blood glucose levels, maintaining good body composition, and replacing and replenishing hormone and nutrient deficiencies can have a demonstrable effect on improving age markers and quality of life. 

In fact, the leading diseases associated with death correlate with aging, so if we can slow the aging process with supplements like Metformin, we can potentially increase longevity and quality of life in humans by decades or more. 

Researchers publish new anti-aging findings discovered when studying improving immune function. Treatment consisted of HGH, metformin, and DHEA. Refer to a reversal of epigenetic aging in adults.

Metformin - Its potential anti-cancer effects

Cancer kills over 590,000 Americans each year. It is the second leading cause of death in the United States. Metformin may aid in reducing the incidence of some cancers.

It is believed anti-cancer benefits of Metformin may occur as an indirect mechanism of better glucose and insulin control. Metformin can also influence inflammatory processes that are reportedly able to help inhibit some forms of tumor progression [Metformin – its potential anti-cancer and anti-aging effects]. Metformin does this through AMPK activation. AMPK activation shares some characteristics related to a catabolic state such as fasting. AMPK activation works to inhibit mTOR signaling, which is a regulator of cell growth. 

Metformin & Berberine Benefits

In addition to Metformin for its anti-cancer characteristics, there is another over-the-counter dietary supplement that offers many of the same benefits. Its name is Berberine. Berberine influences the AMPK pathway in the body in a similar way as metformin.

The main advantage of Berberine is it doesn’t require a prescription. It can be purchased at most vitamin supplement stores throughout the United States. 

Berberine & Metformin Comparison Video

Reversal of (Epigenetic) Aging in Humans: Is it Anti Aging?

Doctors test HGH, metformin, and DHEA to create an average 2.5 year age reversal in cell markers for humans.

Epigenetic age markers are blood markers used to test human age. They surpass chronological age as a more accurate measure of predicting healthspan and longevity. Four markers were used to measure the reversal of epigenetic aging in humans in a recent study. The results were published in May 2019. 

Ref: Reversal of epigenetic aging and immunosenescent trends in humans. <Aging Cell, Reversal of Epigenetic Aging pdf>.

Participants were given human growth hormone, metformin, and DHEA for a period of one year. Results showed an average of 2.5 years of biological age marker reversal.

Share, inform, debate.


Anti-Aging, Dr. David Sinclair Ph.D.

This is one of the latest videos of Dr. Sinclair, Ph.D. Havard, and an anti-aging researcher. Recognized for his past works with resveratrol, sirtuins,  and NAD+ (NMN), he discusses how close we are to anti-aging modalities as medical science in the near future.

What’s more, and more importantly, he offers tips about what he does for himself as a way to share with us all that we can do to improve health, wellness, and longevity. 


What doesn’t kill you makes you stronger. Dr. Sinclair explains on the  Lewis Howes podcast the mechanisms of anti-aging. 

Dr. Sinclair actually argues that aging is a disease. This inherently implies mankind can and will solve it someday. Sinclair states if you don’t get old, it’s rare to get the common diseases associated with death. Therefore, why not attack the aging process much more virtuously? Essentially, we have longevity genes. These genes can be turned on or turned off. Much of it is closely correlated to our lifestyle habits. 

It’s estimated we have about 24,000 genes in our bodies. Perhaps more, perhaps less. Out of all of those, there are only a small fraction of those that regulate longevity in humans.

Dr. Sinclair does much of his research studying sirtuins. He believes the sirtuins are key to making the most impact on wellness and longevity. According to Sinclair, there are 7 sirtuins. 

What’s interesting about Sinclair’s comments, is he believes all these genes, to some degree, are impacted by a unified cause. This is similar to older research related to the Unified Cause of Chronic Disease

It appears from the current research, that if you can influence the sirtuin genes in a positive way, they start a metabolic and molecular cascade of events that influence positively the aging process. 

The pathways Dr. Sinclair and his researchers apparently focus much of their research on are the molecules which influence sirtuin gene expression. Key molecules that can do this include NAD+ and resveratrol to some extent. [Reference Longevity Pathways Diagram pdf].  

The role of metformin is its capacity to influence energy metabolism by expressing AMPK. AMPK acts as a sort of regulator of mTOR. [mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes]. The metformin -> AMPK -> mTOR signaling cascade is just enough to mimic the beneficial effects of calorie restriction related to longevity studied in animals. These pathways appear to work similarly in humans and remain important for understanding them better so we can fight age-related diseases by regulating energy metabolism.

By triggering these pathways correctly, it is feasible to healthspan and longevity significantly over the coming years.  

Metformin Anti Aging Longevity Pathways AMPK mTor
Artwork adapted from The Critical Role of Metabolic Pathways in Aging, Nir Barzilai et. al. 2012

If you would like to use this image on another website, you are free to do so at no charge as long as you backlink to this webpage with one of the following anchor text words [Metformin Longevity Pathways, Metformin Anti Aging, or Anti-Aging and Metformin]. Please refer to our link policy on our terms of use page. Contact us at for more information or adaptations. Our goal is to help share this so others may benefit. Please report any technical errors to us if we have errored or omitted something. 


Longevity on a Budget - What can you do?

Dr. Sinclair states the first thing you want to do is “Don’t Smoke.” It damages your DNA and accelerates the aging process. 

His second recommendation is don’t eat too much. Sinclair states that three meals a day, plus snacks are too much. In fact, for many adults, one meal per day may be better. 

You see, one meal per day mimics more of a paleo lifestyle. For thousands of years, humans adapted to feast and famine. The feast is the anabolic (growth state) at the cellular level. The famine state is the catabolic state when our body cleans out and throws away marginal (senescent cells). 

This encourages a “Yin Yang” form of energy metabolism which is beneficial for improving cellular energy metabolism. 

For exercise, Dr. Sinclair suggests periodic routines of high-intensity intermittent training. 

As time passes, much more research will elucidate what we’ve been treating for years in our treatment centers in Mexico and Costa Rica. It is rewarding to see prestigious researchers like Dr. Sinclair openly sharing the potential for human epigenetic “anti-aging” through mainstream social media outlets. 

With proper diet, supplementation, and physician-based monitoring, we can help you with a tailored program to target these age markers and help improve your quality of life.  

Silicon Valley and Anti-Aging

With billionaire tech investors, Hollywood movie stars, and the rich and powerful, age management protocols (including HGH) are routine. Unfortunately, the U.S. healthcare system has been slow to catch up with new innovations in the understanding of the mammalian aging models well studied in top research universities around the world.  

Most Americans cannot afford expensive non-insured age management care. 

That’s where we step in. With treatment centers in Mexico and Costa Rica, we can mimic U.S. elite protocols for 1/3 the cost of clinics inside the USA. We achieve this because prescription drug prices for some of the therapies are 3-times more in the USA. 

What are the benefits of Anti-Aging?

Statistics vary among those who track healthcare expenditures as a percentage of GDP. But we are U.S. healthcare costs are currently hovering over 17% of our GDP.

Why is this important? By tracking these markets as a percentage of GDP, we can better assess the magnitude of poor health due to age-related chronic diseases that financially impacts the country. It’s a huge number. And many in the industry are getting rich profiting from the status quo. 

If a simple anti-aging medication like metformin can help prevent certain age-related chronic diseases, only a small change in our healthcare model can make a huge difference in the savings on healthcare expenditures. 

Our focus at the anti-aging and wellness medical treatment centers is to give you alternatives today at our international treatment centers. We can work with you on an individual level and target your metabolic markers that are already known to be beneficial for aging and longevity.  

Imagine reducing risk factors for (or controlling) the following chronic conditions:

  • Hypertension
  • Heart disease
  • Cancers
  • Stroke risk
  • Diabetes risk

We can target these risk factors today with the proper lifestyle and evidence-based treatment protocols that can show improvements in these markers in weeks or months. Not only can they improve your aging markers, but you will also likely feel better and look better as your body composition and energy levels improve. 

Metformin may help reduce age-related diseases and health care costs.
Estimates based on various sources and consolidated into a summary chart.

For more stats on GDP and health care, please refer to: [expenditure as percent of GDP from 1960 to 2019].

Is Berberine a Good Substitute for Metformin?

Yes. In some cases, it may be a good option. And the best part about Berberine is it does not require a prescription from a medical doctor. You can order it from Amazon. 

In a 2008 study published in Metabolism, the efficacy of Berberine in patients with type 2 diabetes showed that it did regulate glucose and lipid metabolism. The study confirms the hypoglycemic effect of Berberine is similar to Metformin. 

A more recent study of Berberine published in 2018 showed similarly beneficial results in controlling:

Blood glucose and lipid homeostasis

  1. Anti-obesity
  2. Cardiovascular protection
  3. Anti-tumor Activity
  4. Anti-Inflammation

These pathways are better understood now and relate closely to the metabolic pathways chart shown above. By influencing AMPK and mTOR pathways, this offers similar effects shown on calorie restriction related to longevity. For more information please reference [Metformin and Berberine, two versatile drugs in the treatment of common metabolic diseases].

In addition to berberine as a natural supplement for influencing metabolic support, other natural supplements like turmeric or curcumin have also shown benefits. 

Anti-Aging and Wellness Center by Age Metrics Medical S. A.

The Anti-Aging & Weight Loss Center by Age Metrics Medical is part of the original Anti-Aging and Wellness Medical Clinic (Est. 2013). The clinic is one of the longest-running most successful anti-aging centers in all of Latin America for Weight Loss and Anti-Aging and Wellness therapies. Our doctors are US board-certified in Anti-Aging and Regenerative Medicine by the A4M.

Board-Certified Anti-Aging & Regenerative Medicine A4M

Providing evidence-based Anti-Aging, Weight Loss, and Regenerative therapies. All of our treatment programs are supervised medically by Dr. Jeff Ugalde, MD. He has been part of the Anti-Aging and Wellness team since 2014 serving as its Medical Director. He is the most experienced doctor in Anti-Aging Medicine in Costa Rica. He has over 20 years of experience as a physician and is US board certified by the American Academy of Anti-Aging and Regenerative Medicine. 

Metformin for Anti-Aging Doctor CR
Dr. Jeff Ugalde, M.D.

Medical Experience & Certifications

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