Why am I not Losing Weight on Semaglutide?
When people ask “why am I not losing weight on Semaglutide (Ozempic)?” We describe to them the role of insulin resistance, carb intake, and fat storage. When keeping carbs below 20 grams per day, weight loss occurs in most adults.
Why am I not Losing Weight on Semaglutide (Ozempic/Wegovy)
Are you taking semaglutide (Ozempic) to lose weight, but not seeing results? The reason could be insulin resistance, which makes it harder for your body to control blood sugar levels. This leads to your body demanding more insulin production, which causes more fat to be stored. Insulin is the body’s fat-storage hormone.
The solution is to reduce your sugar and carbohydrate intake and increase your healthy fats and proteins. By doing this, your body will enter ketosis, where it burns fat for energy instead of blood sugars. With time, and while taking Wegovy or Ozempic, you should start to see a faster reduction in body fat.
Insulin converts excess carbs to body fat. In overweight people, high insulin levels prevent the conversion of fat tissue to fuel.
One of the key reasons people ask “Why am I not losing weight on semaglutide (Ozempic)” is insulin resistance. For many, insulin resistance is the cause of type 2 diabetes. It becomes increasingly more difficult for the body to produce enough insulin to reduce blood sugars, particularly after a meal high in processed foods and carbohydrates.
Semaglutide is a medication used to treat type 2 diabetes, but it has also been found to aid in weight loss because it controls insulin.
There could be several reasons why you are not losing weight on semaglutide:
Eating too many carbohydrates: This can be monitored by using a simple glucose meter and checking your blood sugar levels following a meal.
Insufficient dosage of Semaglutide: If the dosage of semaglutide (Ozempic) you are taking is too low, it may not be effective in promoting weight loss. Many prescribers limit the dosage to 1 mg once weekly. It may require increasing the dosage to 2 mg once weekly.
Alcohol Consumption: Many people don’t realize that many alcohols contain very high carbohydrates. Also, even low-carbohydrate drinks like vodka and certain wines temporarily stop fat loss until the alcohol is burned off. If you are having difficulty limiting the use of alcohol, but don’t want to stop drinking “cold turkey” then we recommend adding the medication Naltrexone. Naltrazone taken at 50 mg 1 hour before consuming alcohol helps reduce the cravings for alcohol. This method is known as “The Sinclair Method” of alcohol use. The FDA has approved Naltrexone with Biopupron for weight loss as well. In combination with Semaglutide, Ozempic, or Wegovy, it is another tool that promotes fat loss and cravings for alcohol.
Inadequate diet and exercise: Semaglutide is not a magic pill for weight loss. It works best when combined with a healthy diet and regular exercise. If you are not making changes to your diet and exercise routine, you may not see the desired weight loss results. You may even want to speak to your doctor about fasting or fasting-mimicking diets. In the past, these types of diets seemed extreme, but in the modern era, many are successfully using intermittent fasting to help slow the progression of insulin resistance. Many are claiming a complete reversal of type 2 diabetes by going extremely low carb or no carb. Each individual is different so speak to your doctor or one of ours about intermittent fasting.
Medical conditions: Some medical conditions can interfere with weight loss, even when using medications like semaglutide. Your doctor can help you determine if any underlying medical conditions are preventing weight loss.
Individual variations: Weight loss can be influenced by a variety of individual factors, including genetics, metabolism, lifestyle habits, and other medications. Not everyone will experience the same weight loss results with semaglutide.
If you are concerned about not losing weight on semaglutide, it is important to speak with your doctor. They can help you determine if any adjustments need to be made to your treatment plan or lifestyle habits.
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Eating too Many Carbohydrates
Eating too many carbohydrates may be why you are not losing weight on semaglutide (Ozempic). Limiting carbohydrates can have a significant positive effect on weight loss. The reason is when carbs are too high, your fat-burning capacity decreases. By eating a whole-food diet and limiting carbohydrates to 20 grams or less a day, most people will experience healthy weight loss.
Many remember Dr. Atkins and the Atkins diet. Well, more and more researchers are publishing research on the success of this diet for weight loss and the improvement of overall health. During the induction stage of the diet, Atkins asked his patients to go 14 days or more limiting carbohydrate intake to 20 grams or less per day. Depending on how insulin resistant one results in how fast one will drop weight. But watching your blood sugars and reducing processed (high-carb) foods is a good start. Learn to monitor your blood sugars after meals.
Dr. Jason Fung, MD - Obesity Code & Insulin Resistance
For people who still ask “why I am not losing weight on semaglutide, Dr. Jason Fung is a great resource. Here is a brief overview of Dr. Fung.
Dr. Jason Fung is a Canadian nephrologist and obesity expert who has gained popularity for his approach to managing weight and diabetes through intermittent fasting and low-carbohydrate diets.
Dr. Fung received his medical degree from the University of Toronto and completed his residency in internal medicine at the same institution. He later completed a fellowship in nephrology at the University of California, Los Angeles.
In his practice, Dr. Fung helps patients with a variety of health issues related to metabolic syndrome, including type 2 diabetes, obesity, and hypertension. He has become well-known for his advocacy of fasting as a therapeutic tool for managing these conditions.
Dr. Fung’s approach to fasting involves both intermittent fasting (periods of not eating for 16-24 hours) and longer fasts (up to 7-14 days). He emphasizes the importance of maintaining adequate hydration and electrolyte balance during fasting, and encourages patients to work with a healthcare professional when attempting longer fasts.
In addition to fasting, Dr. Fung also advocates for a low-carbohydrate, high-fat (LCHF) diet to help manage insulin resistance and other metabolic issues. He encourages patients to prioritize whole foods and avoid highly processed foods and added sugars.
Overall, Dr. Fung’s approach to weight management and metabolic health focuses on lifestyle changes rather than medication or surgery. He has authored several books, including “The Complete Guide to Fasting” and “The Obesity Code,” which have become popular resources for people interested in his approach to health and wellness.
Insulin Resistance and Carbohydrates
Insulin resistance is a condition in which the body’s cells become less responsive to insulin, a hormone produced by the pancreas that helps regulate blood sugar levels. When the body is insulin resistant, it requires higher levels of insulin to achieve the same effect on blood sugar as it would with normal insulin sensitivity.
Carbohydrates play a key role in insulin resistance because they are broken down into glucose, which is the body’s primary source of energy. When carbohydrates are consumed, they stimulate the release of insulin from the pancreas to help transport glucose from the bloodstream into cells.
Over time, a diet high in carbohydrates can lead to chronically elevated levels of insulin, which can contribute to insulin resistance. This is because the cells become less responsive to the insulin signal, requiring the pancreas to produce even more insulin to achieve the same effect.
Some researchers believe that chronic insulin resistance may be a key factor in the development of several metabolic disorders, including type 2 diabetes, obesity, and cardiovascular disease. This is why reducing carbohydrate intake is often recommended as a key strategy for improving insulin sensitivity and managing these conditions. By lowering carbohydrate intake, blood sugar and insulin levels can be better controlled, leading to improved metabolic health.
Anti-Aging and Wellness Center by Age Metrics Medical S. A.
The Anti-Aging & Weight Loss Center by Age Metrics Medical is part of the original Anti-Aging and Wellness Medical Clinic (Est. 2013). The clinic is one of the longest-running most successful anti-aging centers in all of Latin America for Weight Loss and Anti-Aging and Wellness therapies. Our doctors are US board-certified in Anti-Aging and Regenerative Medicine by the A4M.


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Providing evidence-based Anti-Aging, Weight Loss, and Regenerative therapies. All of our treatment programs are supervised medically by Dr. Jeff Ugalde, MD. He has been part of the Anti-Aging and Wellness team since 2014 serving as its Medical Director. He is the most experienced doctor in Anti-Aging Medicine in Costa Rica. He has over 20 years of experience as a physician and is US board certified by the American Academy of Anti-Aging and Regenerative Medicine.

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